Laureaten van de projectoproep "Wetenschappelijke Grants 2022"

In januari 2022 lanceerde Stichting tegen Kanker haar tweejaarlijkse oproep voor "Wetenschappelijke Grants 2022" in fundamenteel, translationeel & klinisch onderzoek en in  het onderzoek naar kanker gelinkt aan de blootstelling van asbest.

Dankzij de vrijgevigheid van haar donateurs financiert Stichting tegen Kanker dit jaar 57 projecten van verschillende oncologische onderzoeksinstellingen in het land, voor een totaalbedrag van 25,7 miljoen euro

Deze projecten hebben tot doel de ziekte beter te begrijpen, de genezingskansen verder te vergroten en de levenskwaliteit van mensen met kanker te verbeteren.

De financiering van het Belgisch wetenschappelijk kankeronderzoek is al meer dan 30 jaar de prioritaire missie van Stichting tegen Kanker.  Door het meest innovatieve kankeronderzoek te financieren, helpen we hoop om te zetten in overwinning.

De  laureaten van de selectie door de onafhankelijke wetenschappelijke raden zijn de volgende:

Fundamenteel onderzoek: 29 projecten - € 14 294 198

  • Agostinis Patrizia, KU Leuven
    • Harnessing lysosomal iron homeostasis to prevent melanoma dissemination
  • Beck Benjamin, ULB
    • A cellular reservoir for metaplasia and cancer initiation in the oesophagus
  • Callewaert Nico, UGent
    • Arming therapeutic CAR-T cells with glyco-engineered suppressors of tumor-infiltrating regulatory T cells.
  • Constantinescu Stefan , Institut de Duve
    • Role of the Human Thrombopoietin Receptor in Myeloproliferative Neoplasms and transition to Secondary Acute Myeloid Leukemia.
  • Cools Jan, KU Leuven
    • EZH2 as a transcriptional activator in T-ALL
  • Corbet Cyril , UCLouvain
    • Towards metabolic targeting of the minimal residual disease in head and neck cancers
  • De Smet Frederik & Vermeirssen Vanessa & Quintens Roel, KU Leuven & UGent & Belgian Nucleair Research Centre
    • Targeting radiation-induced plasticity in Glioblastoma: from fundamental insights to tailored therapeutic opportunities
  • Dierickx Daan, KU Leuven
    • Molecular characterization of hyperactive T cell receptor signaling in peripheral T cell lymphoma to uncover druggable targets
  • Elewaut Dirk, UGent
    • Role of endogenous NKT ligands induced by Endoplasmic Reticulum stress in NASH-driven hepatocellular carcinoma
  • Elia Ilaria, KU Leuven
    • Potentiating the metabolic fitness of metastasis associated CD8+ T cells through spatial metabolomics.
  • Fendt Sarah-Maria, KU Leuven
    • Lipid metabolism in obesity and aging-induced cancer metastasis
  • Gilles Christine , ULiège
    • Studying Tissue Factor-dependent membrane protein proteolysis in metastasis
  • Goossens Steven, UGent
    • Oncogenic Role of SOX11 in T-cell acute lymphoblastic leukemia
  • Goriely Stanislas, ULB
    • Targeting Heme Oxygenase-1 expressing tumor associated macrophages to improve cancer immunotherapy
  • Gurzov Esteban & Verslype Chris & Scott Charlotte, ULB & KU Leuven & UGent
    • Obesity-associated Hepatocellular Carcinoma at Single Cell Resolution for Risk Prediction and Novel Therapeutics - HepatoSCRIPT
  • Marine Jean-Christophe, KU Leuven
    • Detection and prevention of early metastatic dissemination of melanoma
  • Mestdagh Pieter, UGent
    • Identifying lncRNA modulators of T-cell activation to enhance immune-checkpoint inhibition therapy
  • Movahedi Kiavash, VUB
    • Macrophage-based cell therapy for brain cancer
  • Noel Agnès, ULiège
    • Targeting ferroptosis resistance of metastasizing cancer cells in lymph node
  • Pastushenko Ievgenia, ULB
    • Defining the role of the frequently mutated epigenetic regulators in cancer
  • Rooman Ilse & Van Laethem Jean-Luc, VUB & ULB
    • InterCePPT: Interfere with Cellular Positioning in the Pancreatic Tumor
  • Speleman Franki , Ugent
    • Single-cell and spatial multi-omics exploration of tumor intrinsic and microenvironment responses to ALK-ATR-CHK1-RRM2 axis drugging in neuroblastoma
  • Tissir Fadel, UCLouvain
    • Glioblastoma prognosis and treatment: Could DIAPH3 be a game-changer?
  • van der Bruggen Pierre , Institut de Duve
    • Cancer-associated neutrophils and their impact on immune cells
  • Van Keymeulen Alexandra , ULB
    • Deciphering the cell plasticity preceding tumor appearance in the mammary gland
  • van Loo Geert, UGent
    • The impact of cell death on the cancer stem cell niche in non-melanoma skin cancer
  • Van Vlierberghe Pieter, UGent
    • PU.1 as driver of leukemic stem cells in human T cell acute lymphoblastic leukemia
  • Vanden Berghe Tom, UAntwerpen
    • Studying the epigenetic regulation of ferroptosis in high-risk neuroblastoma
  • Vleminckx Kris, UGent
    • CRISPR-mediated mapping of genetic dependencies in well-differentiated and dedifferentiated liposarcoma

Translationeel en klinisch onderzoek: 21 projecten - € 9 557 935

  • Baron Frédéric & Humblet-Baron Stephanie & Marchant Arnaud, ULiège & KU Leuven & ULB
    • Systems Vaccinology in allogeneic hematopoietic stem cell transplant recipients
  • Blanpain Cédric, ULB
    • Defining and targeting tumor cell states responsible for resistance to therapy
  • Buisseret Laurence, ULB
    • Impact of immunotherapy on triple-negative breast cancer microenvironement
  • Ceelen Wim & Van Ginderachter Jo, UGent & VUB
    • Engineering the tumor immune microenvironment in colorectal peritoneal metastases by locoregional delivery of toll like receptor agonists
  • De Geest Bruno & Laoui Damya, UGent & VUB
    • A translational cancer vaccination approach based on co-delivery of tumor antigen and Toll-like receptor agonists
  • De Moerloose Barbara , Ugent
    • Integration of genome, epigenome, and transcriptome in juvenile myelomonocytic leukemia and functional analysis of circular RNAs as novel biomarker and/or therapeutic targets.
  • De Preter Katleen, Ugent
    • NIPITplus, a multi-cancer blood test to predict immune checkpoint inhibitor response and monitor toxicity
  • De Wever Olivier, Ugent
    • Exploiting patient-derived models to guide therapeutic decision making in soft tissue sarcoma
  • Desmedt Christine, KU Leuven
    • MetLob: A post-mortem tissue donation study dedicated to Metastatic Lobular breast cancer
  • Flamen Patrick, Institut Jules Bordet
    • Lu-177-FAPI (fibroblast activation protein inhibitor) radioligand therapy in colorectal and pancreatic cancers: Phase 1 study based on dosimetric rationale
  • Jacobs Sandra & Van Damme An, BSPHO
    • Prospective international phase-III trials to improve treatment effectiveness and quality of survival in children with embryonal brain tumours
  • Lambrecht Maarten & De Saint Hubert Marijke, KU Leuven & SCK-CEN
    • ProPOSE: Proton therapy in Pregnancy for Optimal, Safe and Effective cancer treatment
  • Michaux Lucienne, UZ Leuven
    • Improved Cytogenomic Diagnosis in Lymphoma: Opportunities of Optical Genome Mapping and Long-read Sequencing
  • Nuyts Sandra & Nevens Daan, UZ Leuven & UZ Antwerpen
    • PROLoNg-trial: Pembrolizumab and Radiotherapy for OLigometastatic squamous cell carcinoma of the head and Neck cancer: a randomized phase III study
  • Peeters Marc & Verslype Chris, UZ Antwerpen & KU Leuven
    • Impact of ccfDNA on clinical decision making in NEN patients
  • Saussez Sven & Verset Laurine, Université de Mons & Institut Jules Bordet
    • Development of a targeted theranostic platform combining magnetic nanoparticles and radiotherapy for head and neck cancer treatment
  • Sotiriou Christos, ULB
    • Decoding metastatic breast cancer heterogeneity using spatial transcriptomics and AI in the AURORA study
  • Tejpar Sabine , KU Leuven
    • Using mucins as friends in colorectal cancer diagnostics and treatment
  • Van den Eynde Marc , UCLouvain
    • Dimensional characterization of immune and T cells population in metastatic colorectal cancer for the development of circulating immune biomarker.
  • Van der Veken Pieter, UAntwerpen
    • Diagnostic and theranostic targeting of fibroblast activation protein (FAP) with gold nanoparticles decorated with FAPIs and FAPI fragments.
  • Veldeman Liv & Remouchamps Vincent, UGent & CHU UCL Namur
    • Prolonged abdominal deep-inspiration breath hold: clinical translation, monitoring and assessment of cardiac and lung toxicity reduction in prone crawl radiotherapy of breast cancer

Asbest: 7 projecten - € 1 943 370 

  • Bisteau Xavier, ULB
    • Exploiting the sensitivity of malignant pleural mesothelioma to CDK4 inhibitory drugs
  • Cataldo Didier,Uliège
    • CCL5-CCR5 axis : a therapeutic target in cisplatin resistant mesothelioma?
  • Gevaert Kris & Lamote Kevin, UGent & UAntwerpen
    • Validation of a protein biomarker panel in exhaled breath condensate
  • Huaux François, UCLouvain
    • Syndecan-1-expressing macrophages: a new immunosuppressive entity in fibre-induced cancer
  • Meylan Etienne, ULB
    • Analyses of the tumor immune compartment and tumor-associated neutrophils in new generation mouse models of malignant mesothelioma
  • Willems Luc, ULiège
    • Eosinophils propel extracellular traps on mesothelioma cells and inhibit chemoimmunotherapy
  • Zhu Jingjing, Institut de Duve
    • Regulation of anti-tumor immunity by the aryl hydrocarbon receptor in asbestos-induced mesothelioma

Getuigenissen

Nancy Peeters
Op de 1ste plaats mijn 3 schatten!!Lees verder